The core mechanism of action of weight-loss peptides is to mimic the functions of the body’s endogenous regulatory peptides. They target the core pathways of metabolism, appetite and fat metabolism without interfering with irrelevant physiological functions, achieving precise fat loss instead of blind weight loss. The core mechanism is divided into 3 key pathways, which can be better understood when combined with mainstream categories (e.g., GLP-1 receptor agonists, dual-receptor agonists):

1. Regulate the appetite center to reduce calorie intake (Calorie Control)

As one of the most core pathways of weight-loss peptides, it aligns with the body’s physiological feedback, distinguishing itself from forced fasting via dieting.

1. Targeted action: Directly act on the hypothalamic appetite center in the brain, while slowing gastric emptying and inhibiting gastrointestinal peristalsis.
2. Specific principles:

◦ Inhibit brain hunger signals: Block the transmission of hunger, reduce appetite and eating desire, naturally decrease meal portion sizes and snacking frequency without deliberate restraint.

◦ Prolong satiety: Slower gastric emptying enables long-lasting satiety even with small food intake, avoiding overeating and reducing total calorie intake from the source.

◦ No forced hunger distress: It regulates physiological signals rather than blocking nutrient absorption, eliminating palpitations, fatigue and rebound binge-eating caused by dieting.

1. Activate fat metabolism to target fat burning without muscle loss (Metabolism Promotion)

This is the key feature that differentiates weight-loss peptides from laxatives and dieting, achieving “fat loss without muscle loss” and meeting the needs of healthy weight loss.

1. Targeted action: Activate the body’s core fat decomposition pathways, protect muscle tissue and prioritize mobilizing stubborn fat.
2. Specific principles:

◦ Promote fat breakdown: Stimulate fat cells to release fatty acids, accelerate fat oxidation for energy, and convert excess fat into energy for the body to consume.

◦ Prioritize burning stubborn fat: Prioritize mobilizing visceral fat (harmful abdominal fat) and subcutaneous fat, with a more prominent fat-loss effect on visceral fat.

◦ Protect muscle from loss: Unlike dieting (excessive calorie deficit easily breaks down muscle for energy), weight-loss peptides maintain muscle mass; stable muscle mass prevents basal metabolic rate from dropping and avoids weight rebound.

III. Regulate systemic metabolism to improve metabolic disorders (Fundamental Regulation)

This is the core of weight-loss peptides that balance “weight loss + conditioning”, solving the pain point of traditional weight loss that only reduces weight but does not regulate metabolism.

1. Targeted action: Regulate insulin sensitivity, blood glucose and energy metabolism pathways, improving common metabolic abnormalities in obese people.
2. Specific principles:

◦ Enhance insulin sensitivity: Most obese people are accompanied by insulin resistance (glucose is hard to metabolize and easily converted into fat); weight-loss peptides improve insulin efficiency and reduce fat accumulation from glucose conversion.

◦ Regulate energy balance: Optimize the body’s “intake-consumption” balance, shifting the metabolic mode from “fat storage” to “fat burning” and helping build a fat-burning physique.

◦ Assist in regulating blood lipids and blood pressure: Some weight-loss peptides can lower blood lipid indicators such as triglycerides, and have auxiliary conditioning effects on mild metabolic problems associated with obesity.

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